Murcko Algorithm Targeted Libraries

Life Chemicals offers a set of targeted libraries specifically designed and synthesized to target both the aminergic GPCR receptors and the peptidergic GPCR receptors. The compounds have been designed by applying the Murcko fragmentation algorithm on a large set of known GPCR-ligands. The libraries will be made available on a non-exclusive basis. Follow-up synthesis of hits can be performed at reduced cost as the chemistry around the presented scaffolds has been evaluated at Life Chemicals. So we don't only offer the libraries, but also the follow up in the hit-to-lead finding process as well as lead optimization.